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KMID : 0043320170400111271
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Archives of Pharmacal Research
2017 Volume.40 No. 11 p.1271 ~ p.1277
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Diacylglycerol acyltransferase 1 (DGAT1) inhibition by furofuran lignans from stems of Acanthopanax senticosus
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Li Ban Ban
Li Jia Lin
Li Na
Qi Shi Zhou
Lee Hyun-Sun
Zhang Le
Xing Shan Shan
Tuo Zhen Dong
Cui Long
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Abstract
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Two new furofuran lignans were isolated from the stems of Acanthopanax senticosus, along with seven known compounds. Their structures were all determined by spectroscopic analyses and chemical methods. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Compounds 1 and 2 were found to exhibit selective inhibitory activity on DGAT1 with IC50 values 89.5 ± 1.5 and 57.5 ± 1.3 μM, respectively.
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KEYWORD
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Acanthopanax senticosus, Araliaceae, DGAT, Furofuran lignans
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